seizure-control effect of levatiracetam on juvenile myoclonic epilepsy and other epileptic syndromes: literature review of recent studies
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چکیده
how to cite this article: hashemiaghdam a, sharifi a, miri m, tafakhori a. seizure-control effect of levatiracetam on juvenile myoclonic epilepsy and other epileptic syndromes: literature review of recent studies. iran j child neurol. spring 2015;9(2):1-8. abstract objective various epileptic syndromes may present in adolescence and juvenile myoclonic epilepsy (jme) is known to be the most common idiopathic generalized epileptic syndrome presenting itself with different types of seizure activity. the exact etiology of jme is still unknown, but hypoxia, storage disease, toxic-metabolic disorders, drug reactions, and neurodegenerative disorders have been revealed to cause disease manifestation. previous research shows that jme includes 5–10% of all cases diagnosed with epilepsy. it is estimated to include 18% of idiopathic generalized epilepsies. females are at higher risk of developing this condition. levatiracetam (lev) is an anti-epileptic drug that has become one of the most used drugs for the management of epileptic syndromes. it has less drug interactions, milder side effects, and broad-spectrum efficacy to make it an ideal drug to control seizures. different mechanisms of actions have made lev a novel anti-epileptic drug. this new medication can be used as a mono- or add-on therapy to previous anti-epileptic drugs. one of the clinically valuable pharmacological aspects of lev is that it can be started at a high therapeutic dosage and is well tolerated. the median starting dosage varied according to patients underlying disease, age, and disease severity. we have also discussed the effect of lev on other epileptic syndromes, which showed promising results in both adults and children. in childhood epilepsy, there is evidence proving that a higher rate of behavioral disturbances with neurological disorders can be improved by lev therapy. finally, our review showed the beneficial effects of lev on seizure-control in different epileptic syndromes especially as a monotherapy.
منابع مشابه
Seizure-Control Effect of Levatiracetam on Juvenile Myoclonic Epilepsy and Other Epileptic Syndromes: Literature Review of Recent Studies
Introduction Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized epileptic syndrome, mostly initiated before adolescence. It is usually preceded by myoclonic jerks (sudden brief involuntary muscle spasm) in the second decade of life. JME may be presented with different types of seizure activity. Simple bilateral myoclonic seizure is the most seen clinical presentation of...
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Juvenile myoclonic epilepsy.
2. In treatment of juvenile myoclonic epilepsy, the following is true except: a. Phenobarbitone is an effective treatment for generalized tonic seizures and myoclonic seizures b. Lamotrigine exaggerates myoclonic seizures in 50% of patients c. Levetiracetam has potent antimyoclonic effects d. Life long treatment with a proper AED is recommended for juvenile myoclonic epilepsy e. Pregabalin is a...
متن کامل[Juvenile myoclonic epilepsy].
CONCLUSION We conclude that despite inevitable variability the clinical picture of JME is characteristic. It is easy to diagnose JME if one thinks of it while the history should be thoroughly analyzed. An EEG recording during sleep confirms the diagnosis. An early diagnosis of JME permits adequate prognosis of the subsequent course of epilepsy, and adequate therapy brings remission in most of t...
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عنوان ژورنال:
iranian journal of child neurologyجلد ۹، شماره ۲، صفحات ۱-۸
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